PP-027 Obstetrical and neonatal outcome of premature rupture of amniotic membranes before 28 weeks of gestatio

Children born from mothers with hypertensive disorders during pregnancy and experiencing fetal growth delay are at an increased risk of developing motor, neurological, cognitive, and learning disorders, as well as cerebral palsy. Delay in language development (DLD) is one of the common long-term outcomes of fetal neurodevelopmental disruption. DLD entails a delay in the timely development of skills related to sound reproduction and speech compared to established average statistical norms depending on age. Purpose. The main purpose of the study is to determine the frequency and assess the potential association between the presence of DLD in fetuses of women with hypertensive disorders during pregnancy and the development of perinatal complication.

A retrospective analysis of 1295 exchange cards of pregnant women and delivery records was conducted at the Odessa Regional Perinatal Center. Fetal growth delay was diagnosed in 130 (10.03%) cases of singleton pregnancies in women with hypertensive disorders. Additionally, a prospective study and analysis of neurodevelopmental data of children up to 3.5 (±3 months) years old were conducted by surveying parents of children from the selection group with hypertensive disorders.

Delay in language development was noted in 43.24% of the selection group children. Depending on the severity degrees, they were distributed as follows: Grade I - 9 children (15.48%) had a complete absence of speech by the age of 3; Grade II - 8 children (13.76%); Grade III - 16 children (27.52%). Regarding the development of motor skills according to age, the following data were obtained: 18.92% of children had a delay in the development of the head fixation skill within an acceptable time frame; 32.68% had a delay in the skill of pulling up legs; 8.6% of children over 12 months old could not stand even with an additional support point fixation. It was established that the group with delayed neurodevelopment is under the supervision of a pediatric neurologist - 25 children (43.24%).

Thus, it was established that children born with fetal growth delay from mothers with hypertensive disorders are a high-risk group for the manifestation of long-term adverse perinatal outcomes. It was noted that the most significant deviations from age norms were found in children with DLD from mothers whose pregnancy was complicated by preeclampsia of moderate and severe degrees. The obtained results are consistent with global statistical data and once again confirm the need to prevent the development of this complication in the course of pregnancy.