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​Cihat Şen, ​Nicola Volpe

Cecilia Villalain, Daniel Rolnik, M. Mar Gil

Managing Editors
Murat Yayla

Statistics Editor
Resul Arısoy

Article info

OP-006 Cardiovascular disease after early-onset preeclampsia. Perinatal Journal 2024;32(2024):5 DOI: 10.59215/prn.24.032supp006

Author(s) Information

Paula Domínguez-del Olmo1,
Ignacio Herraiz2,
Cecilia Villalaín2,
Gema Ruíz1,
Enrique Morales1,
Jose Luis Ayala3,
Jorge Solís1,
Alberto Galindo2

  1. 12 de Octubre University Hospital, Madrid, Spain
  2. 12 de Octubre University Hospital, Fetal Medicine Unit, Obstetrics and Gynecology Service, Madrid, Spain
  3. Complutense University of Madrid, Madrid, Spain

Paula Domínguez-del Olmo, 12 de Octubre University Hospital, Madrid, Spain, [email protected]

Publication History

Manuscript Received: May 02, 2024

Manuscript Accepted: May 02, 2024

Publication date: May 18, 2024

Conflicts of Interest

No conflicts declared.

Early-onset preeclampsia (eoPE) is a hypertensive pregnancy-related complication characterized by endothelial dysfunction manifested before 34 weeks. Literature stated that women with a hypertensive-complicated obstetric history are at increased risk of cardiovascular disease (CVD), situating the postpartum period as an excellent opportunity for effective screening and cardiovascular risk prevention. In this research, we have assesed if the vascular damage caused during an episode of eoPE is associated later on to a higher risk and occurrence of CVD compared to women with normal pregnancies.
An observational, longitudinal, prospective case-control study have been conducted in 50 women with eoPE and a control group of equal size (matched for age, parity, pregestational body mass index and date of delivery). All patients underwent a cardiovascular assessment including a blood-urine test, an atherosclerosis study and a 24-hour blood pressure monitoring. A statical analysis was performed for case-control parameters comparisons; Traditional Framingham calculators were used to estimate the cardiovascular risk in all patients and a Kaplan-Meier analysis was done to estimate the survival function (time without hypertension (HT))
At a median of 7.5 years after delivery, the blood tests results suggest a worse vascular status in the eoPE group; they showed worse BP measurements, especially in the nocturnal period and no differences were found in the atherosclerosis study. The obtained scores from the Framingham calculators were similar in both groups; however, a CVD was present in 44% of eoPE cases vs 10% of controls and chronic HT was diagnosed after delivery in 38% vs 8% of controls (relative risk of 4.7) with a survival time of 7.4+/-0.7 and 11.6+/-0.2, respectively.
Women with a history of eoPE exhibited greater endothelial dysfunction and a higher prevalence of CVD, particularly chronic HT. Current CVD scores underestimate these risks in women with a history of eoPE, so it should be included as a risk factor. 

Hypertensive, pregnancy, preeclampsia, cardiovascular, case-control

Table 1
24-hour blood pressure measurementt
Figure 1
Kaplan-Meier analysis