OP-006 Cardiovascular disease after early-onset preeclampsia

Paula Domínguez-del Olmo; Ignacio Herraiz; Cecilia Villalaín; Gema Ruíz; Enrique Morales; Jose Luis Ayala; Jorge Solís; Alberto Galindo

OP-006 Cardiovascular disease after early-onset preeclampsia

Paula Domínguez-del Olmo, Ignacio Herraiz, Cecilia Villalaín, Gema Ruíz, Enrique Morales, Jose Luis Ayala, Jorge Solís, Alberto Galindo

Article info

OP-006 Cardiovascular disease after early-onset preeclampsia. Perinatal Journal 2024;32(2024):5 DOI: 10.59215/prn.24.032supp006

Author(s) Information

Paula Domínguez-del Olmo¹,

Ignacio Herraiz²,

Cecilia Villalaín²,

Gema Ruíz¹,

Enrique Morales¹,

Jose Luis Ayala³,

Jorge Solís¹,

Alberto Galindo²

12 de Octubre University Hospital, Madrid, Spain
12 de Octubre University Hospital, Fetal Medicine Unit, Obstetrics and Gynecology Service, Madrid, Spain
Complutense University of Madrid, Madrid, Spain

Correspondence

Paula Domínguez-del Olmo, 12 de Octubre University Hospital, Madrid, Spain, [email protected]

Publication History

Manuscript Received: May 02, 2024

Manuscript Accepted: May 02, 2024

Publication date: May 18, 2024

Conflicts of Interest

No conflicts declared.

Objective

Early-onset preeclampsia (eoPE) is a hypertensive pregnancy-related complication characterized by endothelial dysfunction manifested before 34 weeks. Literature stated that women with a hypertensive-complicated obstetric history are at increased risk of cardiovascular disease (CVD), situating the postpartum period as an excellent opportunity for effective screening and cardiovascular risk prevention. In this research, we have assesed if the vascular damage caused during an episode of eoPE is associated later on to a higher risk and occurrence of CVD compared to women with normal pregnancies.

Methods

An observational, longitudinal, prospective case-control study have been conducted in 50 women with eoPE and a control group of equal size (matched for age, parity, pregestational body mass index and date of delivery). All patients underwent a cardiovascular assessment including a blood-urine test, an atherosclerosis study and a 24-hour blood pressure monitoring. A statical analysis was performed for case-control parameters comparisons; Traditional Framingham calculators were used to estimate the cardiovascular risk in all patients and a Kaplan-Meier analysis was done to estimate the survival function (time without hypertension (HT))

Results

At a median of 7.5 years after delivery, the blood tests results suggest a worse vascular status in the eoPE group; they showed worse BP measurements, especially in the nocturnal period and no differences were found in the atherosclerosis study. The obtained scores from the Framingham calculators were similar in both groups; however, a CVD was present in 44% of eoPE cases vs 10% of controls and chronic HT was diagnosed after delivery in 38% vs 8% of controls (relative risk of 4.7) with a survival time of 7.4+/-0.7 and 11.6+/-0.2, respectively.

Conclusion

Women with a history of eoPE exhibited greater endothelial dysfunction and a higher prevalence of CVD, particularly chronic HT. Current CVD scores underestimate these risks in women with a history of eoPE, so it should be included as a risk factor.

Keywords

Hypertensive, pregnancy, preeclampsia, cardiovascular, case-control

	File/Dsecription
	Table 1 24-hour blood pressure measurementt
	Figure 1 Kaplan-Meier analysis

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OP-006 Cardiovascular disease after early-onset preeclampsia

Article info

Author(s) Information

Correspondence

Publication History

Conflicts of Interest

Objective

Methods

Results

Conclusion

Keywords