Evaluation of conservative and radical surgical outcomes in placenta previa and accreta cases

Objective

To evaluate our 5-year clinical experience in the management of cases with placenta previa together with placental attachment anomalies and the activity of the hypogastric artery ligation (HAL) for the protection of uterus.

Methods

The cases who had cesarean section and were established the diagnosis of placenta previa and accreta between 2009 and 2014 in the Department of Obstetrics and Gynecology, Faculty of Medicine, Mustafa Kemal University were evaluated retrospectively. The medical files of the patients were analyzed and their demographic characteristics, and surgical and conservative approaches were evaluated.  Hysterectomy rates after cesarean section of the patients who did and did not undergo hypogastric artery ligation were compared.

Results

In the evaluation of 67 placenta previa cases included in the study, 32 patients were applied post-cesarean hysterectomy, 40 patients were applied HAL, 12 patients were applied uterine sutures and 3 patients were applied Foley catheter. All of the patients who were applied uterine suture and Foley catheter were in the non-hysterectomy group. It was found that 27 (67.5%) of 40 patients who had HAL were applied post-cesarean hysterectomy and 5 of 27 patients who did not have HAL were applied post-cesarean hysterectomy, and there was statistically a significant difference between groups (p=0.001). In the pathology results of the patients who had hysterectomy, it was reported that 8 (25%) patients did not have accreta, 11 (34.4%) patients did not have increta, 10 (31.3%) patients did not have percreta and 3 (9.4%) patients did not have placental invasion. In terms of complications, it was found that 9 cases had bladder injury, one case had vaginal cuff hematoma and one case had disseminated intravascular coagulopathy. In neonatal outcomes, mean delivery week was 35.2±5.7, birth weight was 2674 g, 1-minute and 5-minute Apgar scores were 6.7 and 7.8, respectively. Fetal anomalies were observed in two newborns.

Conclusion

In cases with placenta previa in company with placental attachment anomaly, conservative surgical approach can be an alternative method. However, organ protection activity of HAL in such cases is considered to be suspicious.

Keywords

Placenta previa, hypogastric artery ligation, placental attachment anomaly.

Introduction

Placenta previa (PP) is defined as placental tissues being near or over internal cervical os. This condition with severe hemorrhage and early delivery potential has an incidence rate of 3.5–4.6 per 1000 deliveries. While its prevalence is reported more frequently in the early weeks of gestation, most of the cases recover spontaneously in the advanced weeks.[1] However, a dramatic increase has been observed recently in the incidence of placenta previa together with increased cesarean rates.[2] Although antenatal diagnoses have been improved by ultrasonography and magnetic resonance imaging (MRI), placenta previa and especially concomitant placental attachment anomalies may cause postpartum massive hemorrhage.[3,4] In patients with placenta accreta, an increase also in fetal mortality, disseminated intravascular coagulopathy (DIC) and infection can be observed. Standard approach in such patients is to carry out hysterectomy.[5] However, the information is limited for the most appropriate management in patients who especially request fertility. Uterine compression sutures and hypogastric artery ligation (HAL) or embolization appear as organ protection approaches in such patients.[6,7]
In this study, we aimed to evaluate the conservative and radical surgical approaches applied in our clinic, their outcomes and HAL’s activity in protecting uterus for patients who have placenta previa together with placental attachment anomaly.

Methods

The medical files of the cases who had cesarean section and were established the diagnosis of placenta previa and accreta in the Faculty of Medicine of Mustafa Kemal University between January 2009 and December 2014 were evaluated retrospectively. Cases with marginal and low-lying placenta previa were excluded from the study. Ages, gravida, parity, week of gestation, number of cesarean undergone, newborn weight, 1-minute and 5-minute Apgar scores and fetal anomalies (if any) of the patients were recorded. In addition, operation duration, transfusion need, hospitalization period, intense care need, operative complications, preoperative and postoperative hemogram and hematocrit values were also recorded. From the surgery notes of the patients, the incision type, whether they had HAL or not, uterine saturation, placing intraoperative Foley catheter to uterine lower segment and cervix, and post-cesarean hysterectomy condition were noted. The pathology reports of the patients who had post-cesarean hysterectomy were also reviewed.

Statistics
All statistical analyses of the data were done by using SPSS software, version 22.0 (SPSS, Inc., Chicago, IL, USA). In the evaluation of the data, mean±standard deviation was used.  Availability of normal distribution in continuous variables was evaluated by Kolmogorov-Smirnov test. Descriptive statistics were analyzed via demographic characteristics. Paired samples t-test was used for the comparison of hemogram values while chi square test was used for the comparison of percentage values. p value below 0.05 was considered as statistically significant.   

Results

Among 2276 pregnant women who delivered in the last 5 years, 8 of 81 patients with placenta previa were excluded from the study since they had marginal or low lying placenta previa. Six patients were also excluded from the study due to the missing information in their medical files. As a result, 67 (29/1000) cases were included in the study. The demographic characteristics of the patients are shown in the Table 1. Except four patients, it was reported that all patients had cesarean history. A significant decrease was observed in the hemogram and hematocrit values of patients (p=0.001 and p=0.001, respectively). Pfannenstiel incision was applied in 53 (79%) patients while median hypogastric incision was applied in 14 (21%) patients. Twenty-two patients were applied post-cesarean hysterectomy, 40 patients were applied HAL, 12 patients were applied uterine sutures on placental implantation region and 3 patients were applied Foley catheter (Table 2). All of the patients who were applied uterine suture and Foley catheter were in the non-hysterectomy group. It was found that 27 (67.5%) of 40 patients who had HAL were applied post-cesarean hysterectomy and 5 of 27 patients who did not have HAL were applied post-cesarean hysterectomy, and there was statistically a significant difference between groups (p=0.001) (Fig. 1).  It was found by the pathology results of the patients who had hysterectomy that 8 (25%) patients did not have accreta, 11 (34.4%) patients did not have increta, 10 (31.3%) patients did not have percreta and 3 (9.4%) patients did not have placental invasion. Fifty-one (76.1%) patients needed blood transfusion. Averagely, 2.63 units of erythrocyte suspension were administered. Also, 39 (58.2%) patients needed intense care. In terms of complications, 9 patients had bladder injury, 1 patient had vaginal cuff hematoma and 1 patient developed DIC. In the follow-up period of the patient who had DIC, the patient developed multi-organ failure and died on postpartum 30th day.  In neonatal results, major anomaly was found in two newborns, one being multiple anomaly and other being hydrocephaly.

Discussion

Together with the increase of previous cesarean rates recently, placenta previa cases have been observed more frequently.[2]  Indeed, we found placenta previa in 29 of 1000 deliveries in our study. It is seen that our rate is 7–8 times higher than the values 3.5–4.6 per 1000 deliveries reported in the literature.[1] In terms of the demographic characteristics, our cases were in their 30s, their mean parity was two and almost all had previous cesarean history. Previous cesarean history and multiparity are also major risk factors for placenta previa in our study.[8–10] It is also observed that Pfannenstiel incision is preferred more, operation durations reach 1.5 hour, patients are hospitalized about 5 days and more than half of them require intense care. It is seen that hemogram values decreased significantly after surgery and the patients were administered approximately 2.6 units of erythrocyte suspension.
Together with placenta previa, various rates of placental attachment anomalies were reported. Placental attachment anomaly was reported as 11–25% when there was single cesarean section history together with placental previa, 35–47% when there were two previous cesarean sections and about 40% when there were above three previous cesarean sections.[11–13] In our study, we found attachment anomaly confirmed by histologically in about 43% among all the patients with placenta previa. It was seen that our patients had averagely 2–3 previous cesarean sections. Accreta was reported in 8 patients, increta in 11 patients and percreta in 10 patients. In the study of Sumigama et al.,[14] there were 18 placenta increta and 5 placenta percreta cases in 408 patients with previa. In the study of Grace Tan et al.,[15] 12 of 27 patients were reported to have placenta accreta, one to have placenta increta and 14 to have placenta percreta. It can be considered from the lower rate of placenta accreta in pathological reports that uterus could be protected much in these patients.
Placenta previa increases the risks for antepartum (RR=9.8), intrapartum (RR=2.5) and postpartum hemorrhage (RR=1.9).[1] Therefore, the need for blood transfusion in pregnant women with PP increased compared to those without PP (12% vs. 0.8%).[16] In our study, the need for blood transfusion was 76%. In order to control the hemorrhage, HAL was used the most among surgical procedures; however, post-cesarean hysterectomy was applied at a significant rate in these cases (Fig. 1). This has made us to consider that the intractable hemorrhage seen in PP and/or placental attachment anomalies were not got under control sufficiently by HAL, and therefore hysterectomy would be required in these patients. HAL was first applied to stop refractory hemorrhage seen in cervix cancer.[17] Although rational pelvic blood flow in HAL was decreased about 50% and arterial pressure was dropped in gynecologic and obstetric hemorrhages, blood flow rate decreases since venous pressure is kept stable.[18] The branches from external iliac artery to paravesical and vaginal areas after HAL can explain the failure of HAL in placental attachment anomalies. In some cases, massive blood flow was observed from external iliac artery to anastomosis lines, and even anastomoses with inferior epigastric and inferior mesenteric arteries contributed blood build up of uterus again through uterine artery.[19] It was also shown that the artery was recanalized after HAL, and blood flow in uterine, arcuate and ovarian arteries was sustained.[20,21] In the study of Iwata et al.,[19] the groups which did and did not have HAL were compared in the patients who had cesarean hysterectomy due to placenta accreta, and no difference was found between the groups in terms of hemostasis. It was emphasized in another study that HAL did not decrease morbidity in placenta accreta, expected blood loss or blood transfusion need, and that HAL was not required in the prophylactic routine practice in placenta accreta.[22] There are some studies with small populations suggesting prophylactic hypogastric artery embolization in patients suspected for placenta accreta.[23,24] In this study, HAL was applied before hysterectomy in all patients who had both HAL and hysterectomy.
In our study, among other surgical methods, square-shaped sutures were applied to uterus in 12 patients and Foley catheter was applied in 3 patients. Cho et al.[25] reported that applying square and circular sutures over uterus serosa on placental implantation localization contributed to hemorrhage control. In this study, all of the patients, who had saturation and applied Foley catheter even in a low rate, being in the non-hysterectomy group may be considered that these methods could be preferred first for hemorrhage on implantation region.
Mortality rates up to 7% were reported depending on the complications observed together with placenta previa such as ureter damage, infection and fistula formation in addition to intraoperative and postoperative massive blood loss and transfusion in placenta accreta.[26] In this study, a patient who developed DIC and sepsis after massive hemorrhage and transfusion died on postoperative 30th day. Sumigama et al.[14] reported in their study that one patient with placenta previa died due to massive hemorrhage. In our study, the most severe complication was bladder injury and found in 9 patients. Bladder injury in placenta previa was reported as 1/10,000 in the literature and it was stated that multidisciplinary approach might be required in such patients.[27]
Our neonatal results show mean week as 35, weight as 2600 g and almost normal Apgar scores. Similarly, O’Brien et al.[26] indicated in their study that the patients suspected for placenta accreta had post-hemorrhage delivery need after 35th week at a rate of 93% and 4 out of 8 maternal death were in labors delayed after 36th week. American College of Obstetricians and Gynecologists (ACOG) recommends planning preterm cesarean hysterectomy after 34 weeks of gestation in cases suspected for placenta accreta. Although we observed major anomaly in two fetuses in our study, it was also reported in the literature that placenta previa decreases Apgar score but it is not associated with congenital anomaly and fetal death.[28]

Conclusion

In cases with placenta previa in company with placental attachment anomaly, conservative surgical approach can be an alternative method. However, organ protection activity of HAL in such cases is considered to be suspicious.

References

1. Faiz AS, Ananth CV. Etiology and risk factors for placenta previa: an overview and meta-analysis of observational studies. J Matern Fetal Neonatal Med 2003;13:175–90. [PubMed] [CrossRef] 
2. Bretelle F, Courbière B, Mazouni C, Agostini A, Cravello L, Boubli L, Gamerre M, et al. Management of placenta accreta: morbidity and outcome. Eur J Obstet Gynecol Reprod Biol 2007;133:34–9. [PubMed] [CrossRef] 
3. Levine D, Hulka CA, Ludmir J, Li W, Edelman RR. Placenta accreta: evaluation with color Doppler US, power Doppler US, and MR imaging. Radiology 1997;205:773–6. [PubMed] [CrossRef] 
4. Komulainen MH, Väyrynen MA, Kauko ML, Saarikoski S. Two cases of placenta accreta managed conservatively. Eur J Obstet Gynecol Reprod Biol 1995;62:135–7. [PubMed] [CrossRef] 
5. Committee on Obstetric Practice. Committee opinion no. 529: placenta accreta. Obstet Gynecol 2012;120:207–11. [PubMed] [CrossRef] 
6. Shahin AY, Farghaly TA, Mohamed SA, Shokry M, Abd-El-Aal DE, Youssef MA. Bilateral uterine artery ligation plus B-Lynch procedure for atonic postpartum hemorrhage with placenta accreta. Int J Gynaecol Obstet 2010;108:187–90. [PubMed] [CrossRef] 
7. B-Lynch C, Coker A, Lawal AH, Abu J, Cowen MJ. The B-Lynch surgical technique for the control of massive postpartum haemorrhage: an alternative to hysterectomy? Five cases reported. Br J Obstet Gynaecol 1997;104:372–5. [PubMed] [CrossRef] 
8. Ananth CV, Demissie K, Smulian JC, Vintzileos AM. Placenta previa in singleton and twin births in the United States, 1989 through 1998: a comparison of risk factor profiles and associated conditions. Am J Obstet Gynecol 2003;188:275–81. [PubMed] [CrossRef] 
9. Rasmussen S, Albrechtsen S, Dalaker K. Obstetric history and the risk of placenta previa. Acta Obstet Gynecol Scand 2000;79:502–7. [PubMed] [CrossRef] 
10. Gurol-Urganci I, Cromwell DA, Edozien LC, Smith GC, Onwere C, Mahmood TA, et al. Risk of placenta previa in second birth after first birth cesarean section: a population-based study and meta-analysis. BMC Pregnancy Childbirth 2011;11:95. [PubMed] [CrossRef] 
11. Miller DA, Chollet JA, Goodwin TM. Clinical risk factors for placenta previa-placenta accreta. Am J Obstet Gynecol 1997;177:210–4. [PubMed] [CrossRef] 
12. Clark SL, Koonings PP, Phelan JP. Placenta previa/accreta and prior cesarean section. Obstet Gynecol 1985;66:89–92. [PubMed] 
13. Silver RM, Landon MB, Rouse DJ, Leveno KJ, Spong CY, Thom EA, et al.; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Maternal morbidity associated with multiple repeat cesarean deliveries. Obstet Gynecol 2006;107:1226– 32. [PubMed] [CrossRef] 
14. Sumigama S, Itakura A, Ota T, Okada M, Kotani T, Hayakawa H, et al. Placenta previa increta/percreta in Japan: a retrospective study of ultrasound findings, management and clinical course. J Obstet Gynaecol Res 2007;33:606–11. [PubMed] [CrossRef] 
15. Grace Tan SE, Jobling TW, Wallace EM, McNeilage LJ, Manolitsas T, Hodges RJ. Surgical management of placenta accreta: a 10-year experience. Acta Obstet Gynecol Scand 2013;92:445–50. [PubMed] [CrossRef] 
16. Crane JM, Van den Hof MC, Dodds L, Armson BA, Liston R. Maternal complications with placenta previa. Am J Perinatol 2000;17:101–5. [PubMed] [CrossRef] 
17. Ha K. Ligation of internal iliac arteries for hemorrhage in hysterectomy for carcinoma uteri. Bull Johns Hopkins Hosp 1894;5:53. 
18. Burchell RC. Internal iliac artery ligation: hemodynamics. Obstet Gynecol 1964;24:737–9. [PubMed] 
19. Iwata A, Murayama Y, Itakura A, Baba K, Seki H, Takeda S. Limitations of internal iliac artery ligation for the reduction of intraoperative hemorrhage during cesarean hysterectomy in cases of placenta previa accreta. J Obstet Gynaecol Res 2010;36:254–9. [PubMed] [CrossRef] 
20. Yildirim Y, Gultekin E, Kocyigit A, Yilmaz C, Ertopcu K, Arioz DT. Color Doppler analysis of pelvic arteries following bilateral internal iliac artery ligation for severe postpartum hemorrhage. Int J Gynaecol Obstet 2009;104:22–4. [PubMed] [CrossRef] 
21. Demirci F, Ozdemir I, Safak A, Ozden S, Somunkiran A. Comparison of colour Doppler indices of pelvic arteries in women with bilateral hypogastric artery ligation and controls. J Obstet Gynaecol 2005;25:273–4. [PubMed] [CrossRef] 
22. Eller AG, Porter TF, Soisson P, Silver RM. Optimal management strategies for placenta accreta. BJOG 2009;116:648–54. [PubMed] [CrossRef] 
23. Chou MM, Hwang JI, Tseng JJ, Ho ES. Internal iliac artery embolization before hysterectomy for placenta accreta. J Vasc Interv Radiol 2003;14:1195–9. [PubMed] [CrossRef] 
24. Dubois J, Garel L, Grignon A, Lemay M, Leduc L. Placenta percreta: balloon occlusion and embolization of the internal iliac arteries to reduce intraoperative blood losses. Am J Obstet Gynecol 1997;176:723–6. [PubMed] [CrossRef] 
25. Cho JH, Jun HS, Lee CN. Hemostatic suturing technique for uterine bleeding during cesarean delivery. Obstet Gynecol 2000;96:129–31. [PubMed] 
26. O’Brien JM, Barton JR, Donaldson ES. The management of placenta percreta: conservative and operative strategies. Am J Obstet Gynecol 1996;175:1632–8. [PubMed] [CrossRef] 
27. Abbas F, Talati J, Wasti S, Akram S, Ghaffar S, Qureshi R. Placenta percreta with bladder invasion as a cause of life threatening hemorrhage. J Urol 2000;164:1270–4. [PubMed] [CrossRef] 
28. Lal AK, Hibbard JU. Placenta previa: an outcome-based cohort study in a contemporary obstetric population. Arch Gynecol Obstet 2015;292:299–305. [PubMed] [CrossRef] 

	File/Dsecription
	Table 1. Demographic, clinical and biochemical characteristics of the patients.
	Table 2. Conservative and radical surgical methods applied together with cesarean section.
	Fig. 1. Postpartum hysterectomy distribution in patients who did and did not undergo hypogastric artery ligation (HAL).